Verifiable Science

Nitric Oxide Support is an arginine-based formulation designed to support healthy nitric oxide production, facilitate ammonia and lactate removal to moderate fatigue, maintain acid-base balance and provide antioxidant protection. Arginine, a precursor of nitric oxide, supports healthy circulation by promoting endothelial function, blood vessel tone and healthy platelet function, as indicated in several randomized cross-over trials.^1-3 l-Citrulline is a non-essential amino acid that is converted to arginine, enhancing nitric oxide production.⁴ Vitamin C has a dual role, helping to enhance nitric oxide bioavailability and activity as well as providing blood vessel endothelial antioxidant protection.^5,6 This formula offers Krebs cycle intermediates in the form of alpha ketoglutarate and malate for additional energy support.⁷ Arginine may protect muscles from oxidation and moderate lactate dehydrogenase activity during intense exercise. In one study, citrulline malate provided potential support for aerobic energy production and fatigue reduction.⁸ Double blind, placebo-controlled studies indicate that arginine and citrulline helps lessen muscle fatigue and maintain healthy acid-base balance, primarily by serving as intermediates in the urea cycle, which helps to eliminate ammonia.